Through the CADTH Common Drug Review (CDR) process, CADTH undertakes reviews of drug submissions, resubmissions, and requests for advice, and provides formulary listing recommendations to all Canadian publicly funded federal, provincial, and territorial drug plans, with the exception of Quebec. This report was prepared by the Canadian Agency for Drugs and Technologies in Health (CADTH). The objective of this review is to evaluate the beneficial and harmful effects of aripiprazole (oral tablets 2 mg, 5 mg, 10 mg, and 15 mg) as an adjunct to ADT for the treatment of MDD in adult patients who had an inadequate response to prior ADT during the current episode. Despite the availability of various ADTs, as many as 50% to 60% of patients do not respond to ADT.Īripiprazole (Abilify) is an atypical antipsychotic (AAP) and is the only drug approved by Health Canada for the adjunctive treatment of MDD in adults who had an inadequate response to prior ADT. Traditional antidepressant therapy (ADT) is the mainstay of treatment. The goal of treatment in patients with MDD is the resolution of symptoms (remission) in order to restore psychosocial and occupational functioning. Because of its early age of onset and frequent recurrences, MDD is also among the leading causes of disability, as measured by disability-adjusted life-years, worldwide. According to the Global Burden of Disease Study and other studies, MDD is a major cause of disability. The prevalence of MDD is twice as high for women as for men, but this difference declines with age. MDD is one of the most prevalent chronic conditions in Canada, with an annual prevalence reaching 4.8% and a lifetime prevalence of 10.8% of the population. The duration of MDEs can also vary significantly in duration, ranging from weeks to years. The clinical manifestation of MDD is heterogeneous. Major depressive disorder (MDD) is characterized by the occurrence of one or more major depressive episodes (MDEs), which persist for at least two weeks and are characterized by a depressed mood and/or markedly diminished interest or pleasure in all, or almost all, activities.
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